Donald Trump swept to victory in the Mississippi and Michigan presidential primaries Tuesday, deepening his grip on the Republican nominating contest.
Democrat Hillary Clinton easily carried Mississippi but was locked in a close race with rival Bernie Sanders in Michigan.
The primaries offered Trump and Clinton a chance to pad their leads and start turning toward the general election.
But Sanders, a Vermont senator, was hoping to prevent a Clinton coronation with a strong showing in Michigan, the night's biggest prize and the first Midwestern industrial state to vote in the 2016 race.
With votes in Michigan still being counted, Clinton glossed over her contest with Sanders and jabbed at the Republicans and their chaotic nomination fight.
"Every time you think it can't get any uglier, they find a way," she said. "As the rhetoric keeps sinking lower, the stakes in this election keep rising."
Trump, too, turned an eye toward the Democrats and the November election, emphasizing the importance of helping Republican senators and House members get elected.
Having entered Tuesday's contests facing a barrage of criticism from rival candidates and outside groups, he reveled in overcoming the attacks.
"Every single person who has attacked me has gone down," Trump said at one of his Florida resorts.
In his typically unorthodox style, the billionaire real estate mogul was flanked by tables packed with his retail products, including steaks, bottled water and wine.
While a handful of recent losses to Texas Sen. Ted Cruz have raised questions about Trump's durability, Tuesday's contests marked another lost opportunity for rivals to slow his momentum.
Ohio Govenor John Kasich had campaigned furiously in Michigan in recent days. He's yet to win a primary but hoped a good showing in Michigan would give him a boost heading into next week's crucial contest in his home state.
Speaking to a crowd in Lansing, Kasich said a strong showing in Michigan would show the country "that it's a new day in this presidential campaign."Republicans were also holding contests Tuesday in Hawaii and Idaho.
Republican candidates were fighting for 150 delegates, while 179 Democratic delegates were at stake in the party's two primaries. The delegates will select each party's presidential nominee at national conventions in July.
The economy ranked high on the list of concerns for voters heading to the polls in Michigan and Mississippi. At least 8 in 10 voters in each party's primary said they were worried about where the American economy is heading, according to early exit polls conducted for The Associated Press and television networks.
Among Democrats, 8 in 10 voters in both states said the country's economic system benefits the wealthy, not all Americans.
Sanders has sought to tap into that concern, energizing young people and white working-class voters with his calls for breaking up Wall Street banks and making tuition free at public colleges and universities.
Michigan, with big college towns and a sizeable population of working-class voters, should be a good fit for him.
But Clinton has led in polling. Sanders' troubles with black voters were evident once again Tuesday. Clinton won nearly 9 in 10 black voters in Mississippi.
Tuesday's contests are a prelude to next week's high-stakes primaries in Florida and Ohio.
Like Kasich, Rubio must win his home state in order to remain a viable contender.Rubio has received endorsements from a steady stream of senators, governors and other high-profile Republican officials.
But his backing from voters has lagged, and he entered Tuesday's contests with just a pair of victories in the Minnesota caucuses and Saturday's Puerto Rico primary.
If Rubio and Kasich can't win at home, the Republican primary appears set to become a two-person race between Trump and Cruz.
The Texas senator is sticking close to Trump in the delegate count and with six states in his win column, he's arguing he's the only candidate standing between the brash billionaire and the Republican nomination.During a campaign stop at a North Carolina church Tuesday, Cruz took on Trump for asking rally attendees to raise their hands and pledge their allegiance to him.
Heading into Tuesday, Trump led the Republican field with 384 delegates, followed by Cruz with 300, Rubio with 151 and Kasich with 37. Winning the GOP nomination requires 1,237 delegates.
Among Democrats, Clinton had accumulated 1,134 delegates and Sanders 502, including superdelegates, party leaders and elected officials who can vote for the candidate of the choice at the convention. Democrats need 2,383 delegates to win the nomination.